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acute exacerbation of chronic obstructive pulmonary disease
Acute exacerbation of COPD also known as acute exacerbations of chronic bronchitis (AECB) is a sudden worsening of COPD symptoms (shortness of breath, quantity and color of phlegm) that typically lasts for several days. It may be triggered by an infection with bacteria or viruses or by environmental pollutants. Typically, infections cause 75% or more of the exacerbations; bacteria can roughly be found in 25% of cases, viruses in another 25%, and both viruses and bacteria in another 25%. Airway inflammation is increased during the exacerbation resulting in increased hyperinflation, reduced expiratory air flow and worsening of gas transfer.
As COPD progresses, exacerbations tend to become more frequent, the average being about three episodes per year.〔(【引用サイトリンク】url=http://www.merckmanuals.com/professional/pulmonary_disorders/chronic_obstructive_pulmonary_disease_and_related_disorders/chronic_obstructive_pulmonary_disease_copd.html?qt=&sc=&alt= )〕
== Signs and symptoms ==
An acute exacerbation of COPD is associated with increased frequency and severity of coughing.〔 It is often accompanied by worsened chest congestion and discomfort. Shortness of breath and wheezing are present in many cases.〔 Exacerbations may be accompanied by increased amount of cough and sputum productions, and a change in appearance of sputum. An abrupt worsening in COPD symptoms may cause rupture of the airways in the lungs, which in turn may cause a spontaneous pneumothorax.〔
In infection, there is often weakness, fever and chills. If due to a bacterial infection, the sputum may be slightly streaked with blood and coloured yellow or green.〔(> Acute Exacerbations of Chronic Bronchitis ). Retrieved Mars 13, 2010〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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